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Nicholls, MBBS, PhD, director of the Monash Victorian Heart Institute and professor of cardiology at Monash University in Melbourne, Australia, and colleagues randomly assigned 13,165 participants with type 2 diabetes and atherosclerotic cardiovascular disease (ASCVD) to a maximum tolerated dose of 5 mg, 10 mg or 15 mg once-weekly subcutaneous tirzepatide (Mounjaro, Eli Lilly) or 1.5 mg of once-weekly subcutaneous dulaglutide (Trulicity, Eli Lilly) with sham dose escalation
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Semaglutide, which is administered via self-injection every week, works by suppressing a persons appetite by mimicking the hormone GLP-1, which is released after eating
Although these agents produce substantial and sustained weight reduction, emerging clinical observations suggest that chronic therapy may be accompanied by changes in lean mass trajectory, reduced protein intake, and micronutrient insufficiency
